Sepsis - Paper Rankings

Papers ranked by AI-analyzed total score

Rank	Paper Title	Total	Rigor	Innovation	Journal	Clinical
1	A consensus blood transcriptomic framework for sepsis. Nature medicine • 2025-10-01	93.0	9	10	10	8
2	Human proteome distribution atlas for tissue-specific plasma proteome dynamics. Cell • 2025-04-10	91.5	9	9	9	10
3	A consensus immune dysregulation framework for sepsis and critical illnesses. Nature medicine • 2025-10-01	91.5	9	9	10	9
4	IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression. The Journal of clinical investigation • 2025-09-02	90.0	9	9	10	8
5	Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis. Nature immunology • 2025-12-04	90.0	9	9	9	9
6	Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis. The Journal of clinical investigation • 2025-03-03	90.0	9	9	9	9
7	Metagenomic signatures of extraintestinal bacterial infection in the febrile term infant gut microbiome. Microbiome • 2025-03-25	88.5	9	9	8	9
8	A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis. Science translational medicine • 2025-11-26	88.5	9	9	9	8
9	Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. The Lancet. Respiratory medicine • 2026-03-20	88.5	9	9	8	9
10	A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection. Cell reports. Medicine • 2026-01-04	88.5	9	9	9	8
11	Low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli. Nature communications • 2025-03-13	88.5	9	9	8	9
12	Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition. Nature communications • 2025-03-21	88.5	9	9	8	9
13	Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury. Nature communications • 2026-02-15	88.5	9	9	9	8
14	A Multicomponent Intervention to Improve Maternal Infection Outcomes. The New England journal of medicine • 2025-11-19	88.5	9	8	10	9
15	Inhibition of Interleukin-40 prevents multi-organ damage during sepsis by blocking NETosis. Critical care (London, England) • 2025-01-17	88.5	9	9	9	8
16	Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice. Nature microbiology • 2025-01-09	88.5	9	9	8	9
17	Microbiota-derived isovalerate ameliorates sex-specific gut barrier dysfunction in malnutrition. Proceedings of the National Academy of Sciences of the United States of America • 2026-08-11	88.5	9	9	10	7
18	Activin A activation of Smad3 mitigates innate inflammation in mouse models of psoriasis and sepsis. The Journal of clinical investigation • 2025-03-12	88.5	9	9	9	8
19	Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation. Science (New York, N.Y.) • 2026-01-22	88.5	9	9	10	7
20	Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis. The Journal of clinical investigation • 2025-09-02	88.5	9	9	10	7
21	A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination. Immunity • 2025-02-28	88.5	9	9	8	9
22	Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion. European heart journal • 2025-12-04	88.5	9	9	9	8
23	Macrophage memory emerges from coordinated transcription factor and chromatin dynamics. Cell systems • 2025-02-13	88.5	9	9	8	9
24	Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation. Nature communications • 2025-10-11	87.0	9	9	9	7
25	Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality. Science advances • 2025-02-14	87.0	9	9	8	8
26	Targeting phenol-soluble modulin α3-driven M1 macrophage polarization and necroptosis mitigates MRSA infection in mice. Nature communications • 2026-03-28	87.0	9	9	9	7
27	Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation. eLife • 2025-03-17	87.0	9	9	8	8
28	De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses. Cell • 2025-05-29	87.0	9	9	10	6
29	RPSA-OLFM4 axis governs neutrophil migration against bacterial infection and sepsis. Nature communications • 2026-04-26	87.0	9	9	9	7
30	A randomized, placebo-controlled trial of 13-valent pneumococcal conjugate vaccination to accelerate immune recovery after sepsis. Science translational medicine • 2026-08-12	87.0	9	8	10	8
31	Disease tolerance and infection pathogenesis age-related tradeoffs in mice. Nature • 2026-01-15	87.0	9	9	10	6
32	DLL4+ neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis. The Journal of clinical investigation • 2025-12-15	87.0	9	9	8	8
33	Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial. International journal of antimicrobial agents • 2025-04-12	87.0	9	8	9	9
34	Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation. Cell metabolism • 2025-08-29	87.0	9	9	9	7
35	LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2. Autophagy • 2025-03-11	87.0	9	9	8	8
36	FGF 13 functions as a regulator of the ERK/aerobic glycolysis axis in the inflammatory state during septic lung injury. Nature communications • 2026-02-06	87.0	9	9	9	7
37	Transglutaminase 2 regulates vimentin-dependent proteostasis during macrophage activation. Science advances • 2026-08-28	87.0	9	9	9	7
38	DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis. Nature communications • 2026-03-10	87.0	9	9	9	7
39	Multi-Omics and -Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2025-05-25	87.0	9	9	8	8
40	Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut. Nature communications • 2026-03-25	87.0	9	9	9	7
41	Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells. Cell • 2025-01-02	87.0	9	9	10	6
42	Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation. Journal of immunology (Baltimore, Md. : 1950) • 2026-08-06	87.0	9	9	8	8
43	Prognostic Accuracy of the Phoenix Sepsis Criteria for Mortality in Children With Suspected Infection: A Systematic Review and Meta-Analysis. Critical care medicine • 2026-08-05	87.0	9	8	9	9
44	Soluble CD72 concurrently impairs T cell functions while enhances inflammatory response in sepsis. International immunopharmacology • 2025-01-11	87.0	9	9	8	8
45	Abdominal ultrasound activates afferent vagus nerve fibers and induces anti-inflammatory effects. Proceedings of the National Academy of Sciences of the United States of America • 2026-02-11	87.0	9	9	9	7
46	Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia. Nature cardiovascular research • 2025-08-20	87.0	9	9	9	7
47	Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study. Nature communications • 2025-02-05	87.0	9	9	8	8
48	Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation. Signal transduction and targeted therapy • 2026-04-03	87.0	9	9	8	8
49	Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2026-05-19	87.0	9	9	8	8
50	Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis. Nature communications • 2026-02-26	87.0	9	9	9	7

About Scores

Rigor (0-10, weight 0.40)

Robustness of research methodology

Innovation (0-10, weight 0.30)

Degree of novel approaches or discoveries

Journal (0-10, weight 0.15)

Journal standing (down-weighted per DORA)

Clinical (0-10, weight 0.15)

Potential impact on clinical practice